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2007•Qilu Pharmaceutical AffairsRequires access

Study on determination method of Ginsenoside Rg_1,Rb_1 and Notoginsenoside R_1 in Xinnaozhi Capsules

Bai Bao-guo

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Abstract

OBJECTIVE To estibish an HPLC method to determine Xinnaozhi Capsules,ginsenoside and the notoginsenoside in Xinnaozhi Capsules.METHODS Zorbax C18 column with gradient elution was adopted.Solvent A was acetonitrile and solvent B was water.The gradient program of solvent A was as follows:0～3min,20%～25%;3～15min,25%～45%.The flow rate was 1.0mL·min-1,the detection wavelength was 203nm.RESULTS Ginsenoside Rg1,ginsenosideRb1 and notoginsenoside R1 linearity relation were fine(r≥0.999),average coefficient of recovery(n=5) was 105.68%,(RSD=1.52%),104.34%(RSD=0.7%),102.93%(RSD= 1.26%),respectively.CONCLUSION The method was sensitive,simple,accurate and suitable for the quality control of Xinnaozhi Granules.

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OBJECTIVE To estibish an HPLC method to determine Xinnaozhi Capsules,ginsenoside and the notoginsenoside in Xinnaozhi Capsules.METHODS Zorbax C18 column with gradient elution was adopted.Solvent A was acetonitrile and solvent B was water.The gradient program of solvent A was as follows:0～3min,20%～25%;3～15min,25%～45%.The flow rate was 1.0mL·min-1,the detection wavelength was 203nm.RESULTS Ginsenoside Rg1,ginsenosideRb1 and notoginsenoside R1 linearity relation were fine(r≥0.999),average coefficient of recovery(n=5) was 105.68%,(RSD=1.52%),104.34%(RSD=0.7%),102.93%(RSD= 1.26%),respectively.CONCLUSION The method was sensitive,simple,accurate and suitable for the quality control of Xinnaozhi Granules.

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Available abstract

OBJECTIVE To estibish an HPLC method to determine Xinnaozhi Capsules,ginsenoside and the notoginsenoside in Xinnaozhi Capsules.METHODS Zorbax C18 column with gradient elution was adopted.Solvent A was acetonitrile and solvent B was water.The gradient program of solvent A was as follows:0～3min,20%～25%;3～15min,25%～45%.The flow rate was 1.0mL·min-1,the detection wavelength was 203nm.RESULTS Ginsenoside Rg1,ginsenosideRb1 and notoginsenoside R1 linearity relation were fine(r≥0.999),average coefficient of recovery(n=5) was 105.68%,(RSD=1.52%),104.34%(RSD=0.7%),102.93%(RSD= 1.26%),respectively.CONCLUSION The method was sensitive,simple,accurate and suitable for the quality control of Xinnaozhi Granules.

Key concepts: Ginsenoside Rg1, Gradient elution, Chromatography, Chemistry, High-performance liquid chromatography, Acetonitrile, Solvent, Ginsenoside

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Study on determination method of Ginsenoside Rg_1,Rb_1 and Notoginsenoside R_1 in Xinnaozhi Capsules — Research Paper | ScholarLens