L-thyroxine on the sub-clinical and clinical efficacy in patients with hypothyroidism and blood lipid levels

Objective:To study on subclinical hypothyroidism Levothyroxine,clinical efficacy in patients with hypothyroidism and blood lipid levels.Methods:From July 2006 to June 2010 in our department treatment of subclinical hypothyroidism,clinical hypothyroidism,136 patients,according to their order randomly divided into treatment group and control group 68 patients,two groups were routine treated of hypertension,diabetes,coronary heart disease.Levothyroxine treatment group received 25 μg/d treatment,and the basis of clinical symptoms and laboratory test results to be gradually increasing doses of TSH returned to normal,changed the maintenance dose,maximum dose of 150 μg/d.Control group were given medicine Liuweidihuangwan 8 particles,3 times/d.Two groups were treated continuously for 6 months.Results:The clinical symptoms observed significant improvement in rate of 91.18% in the control group was 47.06% improvement of clinical symptoms,two groups were statistically significant difference(P0.01);observation group and control group comparison of the indicators in the blood TC,TG,ApoB decreased significantly(P0.01 or P0.05).Conclusion:Levothyroxine disease and subclinical hypothyroidism in patients with clinical symptoms of clinical hypothyroidism improved,lowering blood lipids.