Clinical Observation of Treatment Effects to Symptomatic Gastroesophageal Refluence Disease(GERD) with Omeprazole(95 casea)

Objective:To observe the treatment effectiveness to symptomatic gastroesophageal refluence disease(GERD) with omeprazole.Methods:95 patients with GERD were divided randomly into two groups,one which was treated by omeprazole(20mg qd)included 50 cases,the other treated by simitidine(150mg bid)included 45 cases.Two groups were treated for 4 weeks,then checked by endoscope,observed betterment of clinical symptom and esophageal phlogistic.Results:The efficacy of omeprazole group was 91.6%,however simitidine group was 50.4%;In endoscope the betterment of esophageal phlogistic was seen in 70% of the former,but only 29.2% of the latter.The omeprazole group was much better than the simitidine group.Conclusion:It has been well known that omeprazole can deaden gastric acid secreting which can damnify gastric membrane,and improve clinical symptom;However when to esophagealtitis,it works poor;Better effect might get by combining motivity medication.