An evaluation of prostate specific antigen density in prostate biopsies

Objective To study the role of prostate specific antigen density (PSAD) in prostate biopsy. Methods In 173 patients with elevated serum PSA,positive digital rectal examination or abnormal transrectal ultrasonography,prostate biopsy was conducted and the role of PSAD in prostate biopsy was studied. Results The positive rate of prostate tumors was 50.3%.(87/173),84 cases of prostate carcinoma,2 sarcoma and 1 case of transitional cell carcinoma.When serum PSA was 4～20ng/ml and PSAD0.15,the sensitivity and specificity of PSAD were 100% and 0% respectively.If 0.45,these were 18.2% and 100.0%.When PSAD was0.1,the sensitivity,specificity and the predict positive tumor rate were 90.9%,28.9% and 38.5%.When0.15,these were 78.8%,50.0% and 41.3% respectively. Conclusions High suspicion of prostatic cancer should be noted if PSAD is 0.45.If PSAD is 0.05 and serum PSA ranges from 4.0ng/ml to 20.0ng/ml,prostate biopsy is not needed.