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2002•Academic Journal of Kaifeng Medical CollegeRequires access

Role of Prostate Specific Antigen in the Diagnosis of Prostate Carcinoma

Tie Li

Open publisher page 1 citations

Abstract

Objective: To study the role of serum prostate specific antigen (PSA) and prostate specific antigen density (PSAD) in the diagnosis of prostate carcinoma.Methods: PSA and PSAD by means of ELISA technique were assayed and compared in 20 prostate carcinoma patients and in 30 benign prostatic hyperplasia.Results: When the upper normal limit of PSA was set at 4ng/ml, the diagnosic sensitivity was 90.0%, the specificity 53.3% and the accuracy 68.0% in prostate carcinoma. If the upper normal limit of PSA was set at 10ng/ml, the sensitivity,specificity and the accuracy were 80.0%,83.3% and 82.0% respectively. The diagnosis sensitivity of PSAD was 85.0%, the specificity 86.7% and the accuracy 86.0%.Conclusion: PSA assay is the important means to discover prostate carcinoma and PSAD seems to be more reliable. The combined use of both can increase the early diagnostic rate.

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What this paper is about

Objective: To study the role of serum prostate specific antigen (PSA) and prostate specific antigen density (PSAD) in the diagnosis of prostate carcinoma.Methods: PSA and PSAD by means of ELISA technique were assayed and compared in 20 prostate carcinoma patients and in 30 benign prostatic hyperplasia.Results: When the upper normal limit of PSA was set at 4ng/ml, the diagnosic sensitivity was 90.0%, the specificity 53.3% and the accuracy 68.0% in prostate carcinoma. If the upper normal limit of PSA was set at 10ng/ml, the sensitivity,specificity and the accuracy were 80.0%,83.3% and 82.0% respectively. The diagnosis sensitivity of PSAD was 85.0%, the specificity 86.7% and the accuracy 86.0%.Conclusion: PSA assay is the important means to discover prostate carcinoma and PSAD seems to be more reliable. The combined use of both can increase the early diagnostic rate.

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Available abstract

Objective: To study the role of serum prostate specific antigen (PSA) and prostate specific antigen density (PSAD) in the diagnosis of prostate carcinoma.Methods: PSA and PSAD by means of ELISA technique were assayed and compared in 20 prostate carcinoma patients and in 30 benign prostatic hyperplasia.Results: When the upper normal limit of PSA was set at 4ng/ml, the diagnosic sensitivity was 90.0%, the specificity 53.3% and the accuracy 68.0% in prostate carcinoma. If the upper normal limit of PSA was set at 10ng/ml, the sensitivity,specificity and the accuracy were 80.0%,83.3% and 82.0% respectively. The diagnosis sensitivity of PSAD was 85.0%, the specificity 86.7% and the accuracy 86.0%.Conclusion: PSA assay is the important means to discover prostate carcinoma and PSAD seems to be more reliable. The combined use of both can increase the early diagnostic rate.

Key concepts: Medicine, Prostate-specific antigen, Prostate, Urology, Hyperplasia, Carcinoma, Antigen, Prostate cancer

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