A Comparative Study between Ultrasound-guided Prostate Biopsy and Serum PSA and PSA Density

Objective To analysis the relationship between Transrectal ultrasound-guided prostate biopsy and serum prostate specific antigen(PSA)and prostate specific antigen density(PSA)density.Methods In 105 patients with elevated serum PSA,positive digital rectal examination or abnormal transrectal ultrasonography,the transrectal ultrasound-guided prostate biopsy was conducted between 2006 to 2008.The role of PSA and PSAD in prostate biopsy was studied.Results In 105 patients,there were 36 cases of prostate carcinoma(34.3%)and 69 cases of benign prostate hyperplasia(65.7%).PSA and PSAD in the patients with prostate carcinoma were higher than those with benign prostate hyperplasia(P0.01).In the 11 cases of serum PSA less than 4 ng/ml,1 case was prostate carcinoma(9.1%).The positive rate of prostate biopsy elevated with elevated serum PSA(r=0.912,P0.01).The incidence of benign prostate hyperplasia was obviously higher than prostate carcinoma when PSAD less than 0.15,but the incidence of prostate carcinoma elevated when PSAD greater than or equal 0.15(χ2=16.377,P0.01).Conclusion Serum PSA and PSAD have significance in the diagnosis of prostate carcinoma with prostate biopsy.