A random and controlled study on the united treatment with buspirone and paroxetine for depression

Objectives:To investigate the clinical efficacy and side effects of the united treatment with buspirone and the basic medicine(paroxetine,sulpiride and clonazepam)for depression.Methods: 104 cases of patients with depression,coincident with CCMD - 3,were divided into two groups randomly and treated f or four weeks,the observed group(53 cases)was treated with buspirone and the basic medicine,while the control group(51 cases)was only treated with the basic medicine.The clinical efficacy and side effects were assessed with Hamilton Anxiety scale(HAMA) .Hamilton Depression scale(HAMD) ,HAMD total score,seven factors score and Rating Scale for Side Effects( SERS) . Results: After one-week treatment, there were significant differences between the two groups in HAMD total score, anxiety /somatization, variation between day and night, and feeling of despair (P 0.001) .There was no significant difference in overall efficacy, while the improvement in HAMD total score, anxiety/somatization and cognitive disturbance was more obvious in the observed group, in which the main side effects were constipation, dry mouth, tiredness and drowsiness and there was no significant digestive tract discomfort. Conclusions: There are fast efficacy and good compliance in depression patients treated with buspirone unitd with paroxetine. If managed in time, the side effects such as constipation,dry mouth and tiredness do not affect the treatment.