The effects of high-frequency oscillatory ventilation in severe respiratory failure in neonates

Objective: To investigate the effects of high-frequency oscillatory ventilation(HFOV) in the neonates with severe respiratory failure.Methods: 31 newborn(in sever respiratory failure with FiO2 ≥0.8,SPaO2 ≤90 % lasted for more than 2 hours during the conventional mechanical ventilation(CMV) or chest X-ray showed pneumothorax or oxygenation indexes OI40 were changed to HFOV.) The arterial blood gas analysis,arterial to alveoli oxygen ratio(a/A) and the oxygenation index were monitored during the course of the high-frequency oscillatory ventilation.The respiratory mechanics were compared before HFOV treating and after treating,and before withdrawing ventilator.Results: After 2 hours treatment,SPaO2 in HFV group increased to 90%,8 hours with HFOV,the mean airway pressure(MAP) decreased from(0.17±0.02)kPa to(0.12 ±0.02)kPa,arterial to alveoli oxygen ratio(a/A) increased from(0.09±0.02)kPa to(0.23±0.13)kPa,the oxygenation indes(OI) deceased from(32±11) to(13±4),and FiO2 deceased rapidly from(79.81 ±19.23)% to(62.57±21.36)%.With disease improving,the respiratory mechanics were improved significantly(P0.01).Conclusion: HFOV is an effective method for neonatal infants with severe respiratory failure.