High frequency oscillatory ventilation in the treatment of respiratory failure in neonates

Objective To evaluate the effectiveness of high frequency oscillatory ventilation(HFOV) in the treatment of respiratory failure in neonates.Methods Twenty neonates with respiratory failure were managed with HFOV.The lung volume recruitment was performed by increasing the mean airway pressure and lung volume to achieve the arterial oxygen saturation ≥0.9.The heart rate,arterial blood pressure,arterial blood gas and oxygenation index were monitored during the course of the high-frequency protocol.Results During 48 hours after initiating HFOV,the FiO2 decreased from(0.72±0.17) to(0.37±0.17)(F=5.204,P0.05);the oxygenation index decreased from(11.94±4.50) to(2.73±2.24)(F=9.662,P0.05);the median amplitude pressure decreased from(31.67±5.916) cmH2O to(22.00±5.66) cmH2O(F=3.954,P0.05);the mean airway pressure decreased from(10.44±1.88) cmH2O to(8.75±1.39) cmH2O(F=1.030,P0.05).No significant cardiac complication was observed.Conclusion HFOV is safe and effective in treatment of respiratory failure in neonates.