Relative bioavailability of flunarizine in healthy volunteers by HPLC

Aim: To study the pharmacokinetics and relative bioavailability of flunarizine in healthy volunteers Methods: The plasma concentrations of flunarizine for two preparations were determined in 8 healthy male volunteers after an oral dose of 50 mg by high performance liquid chromatography (HPLC) Results: The plasma concentration time curves of these two drugs appeared to fit to one compartment open model The AUC were (1 686±216)μg·h·L -1 and (1 755±151)μg·h·L -1 and the C max values were (172±14)μg·L -1 and (165±15)μg·L -1 and the T max values were(3 27±0 19)h and (3 32±0 22)h,respectively Relative bioavailability of tablet from Henan was (103 7±7 7)% as compared with the tablet from Hderbin Conclusion: The two preparations are bioequivalent