Pharmacokinetics of the Main Component in the Compound Traditional Chinese Medicine Weeping Forsythia in Chicken

Pharmacokinetics of Chlorogenic acid and Baicalin,two active components of the compound traditional chinese medicine Weeping Forsythia were studied in chickens after oral administration of a single dose(20 g/kg).The contents of chlorogenic acid and baicalin were 53 and 158 mg/kg in the compound.Drug concentrations in plasma were determined using high performance liquid chromatography(HPLC) assay.The pharmacokinetic parameters were calculated by 3p97 program.The pharmacokinetic process of Chlorogenic acid and Baicalin were all fitted with no-compartment model.The main pharmacokinetic parameters of chlorogenic acid and baicalin in plasma were as follows: Area under the concentration-time curve(AUC),aera under the moment curve(AUMC),mean residence time(MRT),elimination half-life(t1/2),maximum drug concentration(Cmax),time of reaching maximum drug concentration(tmax) in plasma were(10.59±0.69) and(11.15±0.78)(mg/L)·h,(106.06±3.11) and(138.44±2.86)(mg/L)·h2,(10.01±0.68) and(12.42±0.43)h,(6.93±0.18) and(8.61±0.36)h,(0.98±0.25) and(1.04±0.25) mg/L,(1.93±0.15) and(2.45±0.19) h,respectively.The concentration change of active constituents components in plasma can reflect the metabolism rule of compound in chicken.The double peak of plasma concentration meant that there might be hepatoenteral circulation or stomach intestine circulation during the metabolism process.This study could provide references for the medicine in clinical application.