Expression of nuclear factor-KB, C-myc,ICAM-1 in human colorectal cancer and its significance

Objective To explore the expression of the nuclear factor-kB, C-myc and ICAM-1 in human colorectal cancer and the relationship between NF-kB and the occurrence,the metastasis of human colorectal cancer, and to analyze the clinical significance. Methods Fifty patients with colorectal cancer which had been resected by operation, 16 cases of colorectal adenomas,9 cases of carcinomatous change of colorectal adenoma and 8 cases of normal colon were studied.The expression of NF-icB p65, C-myc and ICAM-1 in the tumors and normal colon were examined by immunohistochemical method.Results NF-kB p65,C-myc were expressed more strongly in the colorectal cancer and carcinomatous change of colorectal adenomas than in colorectal adenoma; C-myc was not expressed in normal colon; NF-kB p65 and C-myc had significant positive correlation with colorectal cancer; NF-kB p65, ICAM-1 were expressed more strongly in the colorectal cancer which had metastasis than in that had no metastasis, and they had striking positive correlation with metastasis of colorectal cancer. Conclusion NF-kB plays an important role in the occurrence and metastasis of colorectal cancer through controlling the transcription of C-myc and ICAM-1, and may become a new target for treatment of colorectal cancer.