2012•Journal of Clinical HematologyRequires access

Changes of laboratory indexes and prognosis with severe hepatitis B before and after plasma exchange

Zhong Wan-fen

Abstract

Objective:To observe the effect of plasma exchange(PE)on indexes of liver and coagulation function and prognosis in patients with severe hepatitis B.Method:Among 75 patients with severe hepatitis B,40 cases treated with PE on the basic medical therapy,35 cases were treated with only basic medical therapy as control group.The indexes of liver and coagulation function were assessed.Result:The indexes of bilirubin(Bil) and alanine transaminase(ALT) decreased(P0.01)and PTA increased(P0.01) after PE.The PE could increase the treat effective rate compare with controls(P0.05).Conclusion:Plasma exchange might be an effective therapy for severe hepatitis B,and could improve the liver function and coagulation function and increase the survival rate of patients with severe hepatitis B.

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Key concepts: Medicine, Internal medicine, Gastroenterology, Liver function, Hepatitis a virus, Bilirubin, Alanine transaminase, Coagulation