Relationship between intensity of coronary artery angiographic lesions and high-sensitivity C-reactive protein or other cardiovascular risk factors

Objective To investigate the relationship between the intensity of coronary artery lesions and the level of high-sensitivity C-reactive protein(hs-CRP). Methods A total of 148 suspective patients(aged 30 ～ 81 years,male 103,female 45) were performed coronary artery angiography and then divided into coronary heart disease group(CHD group,n = 102) and non- coronary heart disease group(control group,n = 46). According to the intensity of coronary artery disorder,CHD group was subdivided into 3 subgroups:single branch lesion,2 branch lesions and 3 branch lesions. The levels of hs-CRP and serum uric acid,glucose and cholesterol were measured and the blood pressure,history of cigarette smoking,hypertension and diabetes were recorded in each group. Results ①The level of hs-CRP in CHD group was markedly higher than that in NCHD group(P 0.05);②The levels of hs-CRP in 2 branch and 3 branch lesions subgroup were markedly higher than that in single branch subgroup(P 0.05).Conclusion Serum hs-CRP is not only a strong independent risk factor of CHD,but also a sensitive index of coronary artery angiographic lesion intensity.