Correlation of serum level of hs-CRP,LP(a),Fig,TB,and UA with coronary artery lesion

Objective:To investigate the changes of serum level of high-sensitivity C-reactive protein,lipoprotein(a),fibrinogen,total bilirubin,and uric acid in patients with coronary artery lesion.Methods: The levels of serum hs-CRP,LP(a),Fig,TB,and UA 418 were analyzed in patients undergoing selective coronary angiography,which were divided into normal group(n=85),coronary artery atherosclerosis group(n=93 cases),coronary artery single-vessel disease group(n=155 cases) and coronary artery multi-vessel disease group(n=85 cases) according to the level of coronary artery stenosis.And the general clinical data,including blood glucose,blood lipids,blood pressure,smoking history and so on were analyzed.Results: Most patients in CHD group had smoking habit and hypertension,diabetes,hyperlipidemia.Compared with patients in non-CHD group,the differences had statistically significant,P0.05.The TB level of patients in CHD group was lower than the normal group,while the remaining four indicators were higher than the normal group,the differences were statistically significant(P0.05).Logistic regression analysis showed that,in addition to UA,the other four are the factors that influence coronary artery disease,in which the hs-CRP has the greatest significance,OR is 1.122.Conclusion: High blood sugar,high blood lipids,hypertension,and smoking history are risk factors for coronary heart disease.With the increasing degree of coronary artery lesion,in addition to significant reduction of TB level,hs-CRP,LP(a) and Fig were significantly increased.In addition to UA,the other indicators can be assessed as a predictor of coronary heart disease,and the hs-CRP has the highest predictive value for coronary heart disease.