The Expressions of COX-2、MMP-9 and VEGF in human glioma and their significance

Objecive To investigate the expressions of COX-2,MMP-9 and VEGF in human glioma.Methods The expressions of COX-2,MMP-9 and VEGF in 55 cases with human glioma and 8 specimens with normal brain tissues were detected by immunohistochemical staining(S-P methods),studing by cytological observation.Results COX-2,MMP-9 and VEGF weren't observed in the normal brain tissue,while they all expressed in the human brain glioma,the difference was statistically significant(P0.05).The expression intensity in different glioma grade groups showed increasing trend by sequence,the difference was statistically significant(P0.05).COX-2 expression was positively correlated with MMP-9 and VEGF expression in glioma(rs=0.631,rs=0.687;P0.05).Conclusions The expression intensity of COX-2,MMP-9 and VEGF were increased with the glioma malignant grades,suggesting that they might be involved in the development and progression of glioma.There was definite correlation between the positive expression of COX-2,MMP-9 and VEGF in glioma,which indicated that the development of glioma was a result of the interplay of many factors.COX-2 may induce the expression of MMP-9 and VEGF to promote the formation of angiogenesis,the invasion and the metastasis of glioma.