Relationship between Expression of Caveolin-1 and Gliomas Cell Proliferation

Objective To explore the expression of caveolin-1 in human gliomas and its effects on the development and cell proliferation of gliomas.Methods The expression and distribution of caveolin-1 and proliferating cell nuclear antigen (PCNA) were determined by immunohistochemical technique in 80 cases of glioma specimens and 9 normal brain tissues.Results Caveolin-1 was expressed positively in all normal brain tissues,and in 39 of 80 cases of glioma specimens,higher in low grade glioma specimens than in high (P0.05).PCNA was not expressed in normal brain tissues,but expressed in 55 cases of glioma specimens,higher in high grade glioma than in low (P0.05).There was negative correlation between expressions of caveolin-1 and PCNA in glioma(r=-0.368,P0.01).Conclusion Caveolin-1 in glioma has depressant effects on tumor cell proliferation,providing a new target for the glioma gene therapy.PCNA can be used as one of prognostic indicators reflecting glioma cell proliferation,malignant degree and its prognosis.