A Clinical Report of Oxygen-ozone Combined With Collagenase Chemonucleolysis in the Treatment of Lumbar Disc Herniation

Objective To assess effect of percutaneous intradiscal oxygen-ozone injection combined with target collagenase chemonucleolysis in the treatment of lumbar disc herniation.Methods 161 patients with lubar intervertebral disc protrusion(LIDP) were divided into two groups randomly.A group of patients(n=81) were treated with collagenase combined oxygen-ozone therapy,but B group of patients(n=80) were treated with collagenase only.After treatment,the patients were followed-up and the adverse effect,complication and therapeutic effect were assessed at 3 months.Results The success rate was 91.4%,90.0% in two groups respectively.There was no statistically significant difference between two groups after 3 months(P0.05).But the adverse effect in A group was less than in B group and there was a statistically significant difference between two groups(P0.05). Conclusion The combination of the collagenase with oxygen-ozone shows significant reductions in adverse effect of collagenase chemonucleolysis,which can be considered as an option for the treatment of lumbar disc herniation.