Expression and Clinical Significance of SKP2 and P27~(KIP1) Proteins in Human Gastric Cacinoma

Objective To investigate the clinical significance of P27~ KIP1 and S-phase kinase-associated protein 2 (SKP2) expression in human gastric carcinoma. Methods The expression of P27~ KIP1 and SKP2 was determined by SP immunohistochemical method in 69 specimens of gastric carcinoma. Results The positive rates of P27~ KIP1 and SKP2 expression were 46.38% and 33.33%, respectively. The positive rate of P27~ KIP1 expression in gastric carcinoma decreased with the poor differentiation,deep invasion and progression of pathological grade (P0.05),while the positive rate of SKP2 expression increased when the differential degree of gastric carcinoma decreased. The positive rate of both the P27~ KIP1 and SKP2 expression was not associated with the patients age, sex,and tumor size and location (P0.05). There was a negative correlation between the P27~ KIP1 and SKP2 expression(P0.01). Conclusion The abnormal expression of P27~ KIP1 and SKP2 may promote cell cycle progression and gastric carcinogenesis. Detecting P27~ KIP1 and SKP2 proteins expression, especially P27~ KIP1, may be helpful for evaluating the malignant degree and prognosis of gastric carcinoma. Ubiquitin-proteasome pathway may play an important role in gastric carcinogenesis.