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Expression and significance of nuclear factor-kappa B in cervical squamous cell carcinoma

Li Ning

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Abstract

Objective To investigate the effect of NF-κB in the pathogenesis of cervical squmous cancer.Methods The expression of the NF-κB p50,NF-κB p65 were examined by real time RT-PCR and immunohistochemical assay in 30 specimens of cervical squamous cell carcinoma tissue and 30 specimens of normal cervical tissue.Results The mRNA expression and proteion positive rate of NF-κB p50,NF-κB p65 in cervical squmous ceu carcinoma were both higher that in the normal cervical tissues(P0.01).Conclusion NF-κB is a new tumor gene related to cervical comcer,and hopeful to become a new treatment target.

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Objective To investigate the effect of NF-κB in the pathogenesis of cervical squmous cancer.Methods The expression of the NF-κB p50,NF-κB p65 were examined by real time RT-PCR and immunohistochemical assay in 30 specimens of cervical squamous cell carcinoma tissue and 30 specimens of normal cervical tissue.Results The mRNA expression and proteion positive rate of NF-κB p50,NF-κB p65 in cervical squmous ceu carcinoma were both higher that in the normal cervical tissues(P0.01).Conclusion NF-κB is a new tumor gene related to cervical comcer,and hopeful to become a new treatment target.

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Available abstract

Objective To investigate the effect of NF-κB in the pathogenesis of cervical squmous cancer.Methods The expression of the NF-κB p50,NF-κB p65 were examined by real time RT-PCR and immunohistochemical assay in 30 specimens of cervical squamous cell carcinoma tissue and 30 specimens of normal cervical tissue.Results The mRNA expression and proteion positive rate of NF-κB p50,NF-κB p65 in cervical squmous ceu carcinoma were both higher that in the normal cervical tissues(P0.01).Conclusion NF-κB is a new tumor gene related to cervical comcer,and hopeful to become a new treatment target.

Key concepts: Immunohistochemistry, Cervical cancer, Pathogenesis, Cervical carcinoma, Basal cell, Pathology, P50, NF-κB

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