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Expression and significance of NF-κB p65 in human cervical squamous cell carcinoma

Shulan Zhang

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Abstract

Objective: To evaluate the significance of NF-κB p65 protein expression in 32 cases of human cervical squmous cancer. Methods: The expression of p65 protein was analyzed by using immunohistochemistry method in 32 cases of cervical squamous cell carcinoma,30 of normal cervical tissue ,and 30 of chronic cervical inflammation. Results: The positive rate of NF-κB p65 protein expression in 32 cases of human cervical squmous cell carcinoma was 68.7%, in contrast, in cases of chronic cervical inflammation was 6.66%, none of the normal tissue exhibited NF-κB p65 protein staining. Significant differences were observed between cervical cell carcinoma,chronic cervical inflammation, and normal tissues. Conclusion: Constitutive activation of NF-κB p65 may lead to oncogenesis. NF-κB p65 may be a new therapy target of human cervical squmous cell carcinoma.

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What this paper is about

Objective: To evaluate the significance of NF-κB p65 protein expression in 32 cases of human cervical squmous cancer. Methods: The expression of p65 protein was analyzed by using immunohistochemistry method in 32 cases of cervical squamous cell carcinoma,30 of normal cervical tissue ,and 30 of chronic cervical inflammation. Results: The positive rate of NF-κB p65 protein expression in 32 cases of human cervical squmous cell carcinoma was 68.7%, in contrast, in cases of chronic cervical inflammation was 6.66%, none of the normal tissue exhibited NF-κB p65 protein staining. Significant differences were observed between cervical cell carcinoma,chronic cervical inflammation, and normal tissues. Conclusion: Constitutive activation of NF-κB p65 may lead to oncogenesis. NF-κB p65 may be a new therapy target of human cervical squmous cell carcinoma.

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Available abstract

Objective: To evaluate the significance of NF-κB p65 protein expression in 32 cases of human cervical squmous cancer. Methods: The expression of p65 protein was analyzed by using immunohistochemistry method in 32 cases of cervical squamous cell carcinoma,30 of normal cervical tissue ,and 30 of chronic cervical inflammation. Results: The positive rate of NF-κB p65 protein expression in 32 cases of human cervical squmous cell carcinoma was 68.7%, in contrast, in cases of chronic cervical inflammation was 6.66%, none of the normal tissue exhibited NF-κB p65 protein staining. Significant differences were observed between cervical cell carcinoma,chronic cervical inflammation, and normal tissues. Conclusion: Constitutive activation of NF-κB p65 may lead to oncogenesis. NF-κB p65 may be a new therapy target of human cervical squmous cell carcinoma.

Key concepts: Immunohistochemistry, Cervical cancer, Cervical carcinoma, Medicine, Inflammation, Carcinogenesis, Pathology, NF-κB

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