Analysis of serum concentration of carbamazepine in 381 cases

OBJECTIVE To analyze the monitoring results of carbamazepine serum concentration in 381 cases of 347 patients.METHODS The carbamazepine serum concentration was measured by fluorescence polarization immunoassay.The carbamazepine serum concentration in 381 cases was compared and analyzed and the clinical effect and adverse drug reaction of the patients were observed.RESULTS There were 311 cases(82.1%) whose carbamazepine serum concentration were between 4 and 12 mg·L-1.Among 311 samples,there were 274 cases who were used with carbamazepine separately and 37 cases who used combination carbamazepine with other antiepileptic drugs,there were 91.6% (285/311)of them whose epilepsy were controlled on the whole or made betterand 3.9%(12/311)of them who appeared adverse drug reaction. There were 51 cases (13.4%) whose carbamazepine serum concentration were less than 4 μg·mL-1. There were 19 cases(5.0%) whose carbamazepine serum concentration were more than 12 mg·L-1 and 84.2%(16/19) of them appeared serve adverse drug reaction.CONCLUSION It is reasonable that the therapeutic window of carbamazepine serum concentration is between 4 and 12 μg·mL-1. The therapeutical drug monitoring of carbamazepine is the important measure which ensures the clinical effect and safety in the medical care.