Analysis of Monitoring Result of Serum Concentration of Carbamazepine in Epileptic Patients

Objective To analyze results of the blood concentration of carbamazepine in epileptic patients drug,combined with clinical efficacy of carbamazepine to provide the basis for clinical therapy.Methods Serum concentrations of carbamazepine in 280 epileptic cases were determined by fluorescence polarization immunoassay.The clinical efficacy and adverse reactions were observed and analyzed.Results Of the total 280 cases monitored,serum concentrations of carbamazepine lower than 4 μg / ml accounted for 30.71%,4-12 μg / ml accounted for 62.50%,serum concentration greater than 12 μg / ml accounted for 6.79%.The effective rates were 33.72%,61.71%,84.21%,respectively.Conclusions Closely monitor serum concentrations of carbamazepine and combined with clinical efficacy can provide objective basis for clinicians to develop individualized regimens,which was important to improve the treatment of epilepsy in safety,effectiveness.