Observation of Immune Effect of Secondary Immunization Among Unsatisfactory Responders to Initial Hepatitis B Vaccination

Objective To observe the immune effect of immunzation with the recombined yeast gene hepatitis B vaccine(HBV)among those who did not well respond to the initial vaccination and to provide evidences for reasonable secondary immunization with hepatitis B vaccine.Methods A total of 560 college freshmen were immunized with hepatitis B vaccine by using 0-,1-,and 6-month schemes respectively,and then inspected the effects of immunization.Results One month after the primary full-access immunization,the anti-HBs positive conversion rate was 77.5%,and there was no significant difference between males and females(P0.05).After the second full-access immunization the total rate of anti-HBs positive convertion was 80.16%,among them,the females' was higher than the males'(P0.05).After the third full-access immunization in large doses,the anti-HBs positive conversion rate was 100%.Conclusion The anti-HBs positive conversion rate among those irresponsive cases after the primary full-access immunization could reach to 100% after the second and third full-access immunization.