Serum-epidemiological Research on Hepatitis B Vaccine Immunization Effect of New-born Infants in Tangshan City

Objective To provide strategy of the rationale for hepatitis B vaccination in non-new born population,the hepatitis B infectious rate,antibody level,hepatitis B vaccine immunization effect and persistency in children were studied.Methods In 2005,in Tangshan,444 serum samples of children aged 015 years old who had clear hepatitis B vaccine immunization history with different vaccination schedule were collected.The HBsAg and anti-HBs were tested and the test results were compared with the data collected in 1992,the year before hepatitis B vaccination program was implemented.The anti-hepatitis B level and the persistency were compared between the regular immunization and the booster immunization.Results In 2005,the HBsAg positive rate in each age group of children was significant lower than that in 1992.The anti-HBs protection rate and antiHBs positive rate declined significantly 5 years after regular immunization,and the anti-HBs positive rate declined to the natural infection level as the year of 1992. The anti-HBs protection rate and anti-HBs positive rate of the children received booster immunization 5 years after regular immunization,were significantly higher than that of children who were not boosted.Conclusion Hepatitis B vaccine immunization is an effective measure to control HBV infection.It is necessary to implement the booster immunization 5 years after the regular immunization to achieve the persistent immune response against HBV.