Analysis of hb vaccine vaccination and immunity effect among the freshemn in chaoyang university

Objective The aim of this study was to investigate the rate of hepatitis B vaccine among the freshmen of three-years and the immunity effect after vaccination, and to provide reference for further prevention and control. Methods 1475 freshmen of three-years were collected,and investigated about hepatitis B vaccinated, and detected the the marker(HBsAg,anti-HBS, HBeAg anti-HBe and Anti-HBc) of hepatitis B; the fivetargets of HBV were showed to be negative, and normal liver function were immunized with hepatitis B vaccine by using 0,1, and 6 months schemes,if freshmen with the negative anti-HBs at the time of one month were immunized with hepatitis B vaccine in large doses by using 0,1, and 2-months schemes. Results Among 1475 freshmen,the rate of hepatitis B vaccinated was 74.03%.After the primary vaccinated for one month,the conversion rate of anti-HBs positive was 76.43%,and no significant difference was found between the conversion rates of males and females(χ2=1.19 P0.05).For freshmen with negative anti-HBs,we used the second full-course immunization with large dose,and the conversion rate of positive anti-HBs was 100%. Conclusion The hepatitis B vaccination is the best effective way of preventing HBV infection,and the revaccination of vaccine is effective and practical way for solving the non-response hepatitis B vaccine.