A comparative study of maprotiline plus fiuoxetine in treatment of depression.

Objective:The aim of this study was to determine the efficacy and safety of maprotiline plus fluoxetine for the depressive patients.Methods:A controlled study was carried out between 61 patients who met the CCMD-3 criteriaon of major depression.The 31 of total patients were treated with maprotiline plus fluoxetine(therapeutic group) and the others were treated with fluoxetine(control group) for 6 weeks.The efficacy was assessed by Hamilton depression rating scale(HAMD) and the safety was assessed by Rating Scale for Side Effects(SERS).Results: After 6 weeks treatment,the efficacy rate of the therapeutic group and control group were 84% and 77%,respectively.The results have no remarkable differences in two groups(P0.05),but therapeutic group's convalescing rate achieved 65% and the control group 37%,The results have remarkable differences in two groups(P0.05).and the therapeutic group took effect more quickly.Conclusions: maprotiline plus fluoxetine is an appropriate method in treatment of depression.