The Correlation between Plasma Homocysteine and Established Risk Factors of Coronary Heart Disease

Objective To explore the correlation between plasma homocysteine(HCY)concentrations and some established risk factors of coronary heart disease(CHD).Methods Plasma HCY concentrations were measured by fluorescence polarization immunoassays(FPIA).Serum triglyceride(TG),total cholesterol(TC),high density lipoprotein-cholesterol(HDL-C)and low density lipoprotein-cholesterol(LDL-C)of 123 CHD patients and 101 controls were measured respectively.Information in medical histories including essential hypertension(EH),diabetes mellitus(DM),related family history(FH)and smoking status were obtained from all participants via a questionnaire.Results ① Plasma HCY concentrations of patients with CHD were higher than that in controls(P0.01).There was significantly higher incidence of HHCY in CHD group than those in control group(36.59% vs 9.90%,P0.01).② There was no correlation between Ievels of HCY and age,sex,TG,TC,HDL-C or LDL-C in the CHD group.There was no discrepancy in Ievels of HCY between cases with different history of EH,DM,FH and smoking status.③ Based on multivariate logistic regression analysis,the odds ratio(OR)of HCY to CHD was 1.238(95% confidence interval,1.109-1.381,P0.01).Conclusion There is no correlation between plasma homocysteine and established risk factors of coronary heart discase.HCY is an independent risk factor of CHD.Detection of the levels of Plasma HCY can be a helpful marker for diagnosing CHD.