The correlation between serum homocysteine and established risk factors of coronary heart disease

AIM: To investigate the correlation between serum homocysteine(HCY) level and some established risk factors of coronary heart disease(CHD).METHODS: The fasting total serum(HCY), serum triglyceride(TG), total cholesterol(TC), high density lipoprotein-cholesterol(HDL-C)and low density lipoprotein-cholesterol(LDL-C) of 105 CHD patients and 48 controls were measured respectively. Prior medical histories including essential hypertension(EH), diabetes mellitus(DM), and smoking status were obtainedform all participants via a questionnaire. RESULTS: ① Serum HCY level was significantly higher in the CHD group than in the control (23±13 μmol/L versus 10±3 μmol/L,P0.01). In the CHD group, 58% of the patients were found to have Hyperhomocysteinemia, the percentage significantly higher than that of the control(17%, P0.01). ②There was no correlation between levels of HCY and age ,TG ,TC ,HDL-C or LDL-C in the CHD group. There was no discrepancy in levels of HCY between cases with different sex, different history of EH,DM and smoking status. ③Based on multivariate non-conditional logistic regression analysis , the odds ratio(OR) of HCY to CHD was 1.505(95%CI 1.270~1.783,P0.01).CONCLUSION:HCY level is significantly elevated in population with CHD and the incidence of hyperhomocysteinemia is also higher. There is no correlation between serum homocysteine and established risk factors of coronary heart disease . HCY is an independent risk factor of CHD.