2004Journal of Injuries and Occupational Diseases of The Eye With Ophthalmic SurgeriesRequires access

The research of VEGF expression in rat's ischemia-reperfusion injurie d retina

Tang Chao-zhen

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Abstract

Objective To study VEGF expression in rat's re tina which injuried by ischemia-reperfusion.Methods The model of rat's retina ischemia-reperfusion was made ,used ISH method to test the VEGFmRNA expression in rat's retina.Results At one hour after ischemia-reperfusion,there was no VEG FmRNA expression in rat's retina,after 12 hours of ischemia-reperfusion,there wa s some VEGFmRNA expressed in retina and reached the hightest level at 48 hours a fter ischemia-reperfusion.Then it began to decrease,but there was VEGFmRNA expre ssion in retina after 72 hours.Conclusion VEGF is very important in rat's retina ischemia-repe rfusion injury.

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What this paper is about

Objective To study VEGF expression in rat's re tina which injuried by ischemia-reperfusion.Methods The model of rat's retina ischemia-reperfusion was made ,used ISH method to test the VEGFmRNA expression in rat's retina.Results At one hour after ischemia-reperfusion,there was no VEG FmRNA expression in rat's retina,after 12 hours of ischemia-reperfusion,there wa s some VEGFmRNA expressed in retina and reached the hightest level at 48 hours a fter ischemia-reperfusion.Then it began to decrease,but there was VEGFmRNA expre ssion in retina after 72 hours.Conclusion VEGF is very important in rat's retina ischemia-repe rfusion injury.

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Available abstract

Objective To study VEGF expression in rat's re tina which injuried by ischemia-reperfusion.Methods The model of rat's retina ischemia-reperfusion was made ,used ISH method to test the VEGFmRNA expression in rat's retina.Results At one hour after ischemia-reperfusion,there was no VEG FmRNA expression in rat's retina,after 12 hours of ischemia-reperfusion,there wa s some VEGFmRNA expressed in retina and reached the hightest level at 48 hours a fter ischemia-reperfusion.Then it began to decrease,but there was VEGFmRNA expre ssion in retina after 72 hours.Conclusion VEGF is very important in rat's retina ischemia-repe rfusion injury.

Key concepts: Retina, Ischemia, Medicine, Reperfusion injury, VEGF receptors, Ophthalmology, Internal medicine, Biology

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