Quantitative study of hepatic dynamic flow in hepatocellular carcinoma by multi-slice CT perfusion

Objective To study the changes of perfusion parameters in hepatocellular carcinoma (HCC) by multi-slice computed tomography (MSCT) perfusion technique. Methods Perfusion CT images were obtained in 30 patients with HCC and 30 control subjects. A single-slice dynamic CT was performed after an intravenous bolus injection of 50 ml of contrast material and continued for 50 seconds at a speed of 4.0 ml/s. The parameters were calculated by deconvolution method, and perfusion maps and quantitative parameters were created. Results For HCC, the decreased parameters such as HBF, HBV, HPP and the increased parameters such as HAP, HAI in HCC were differentiated from the apparently normal liver adjacent to cancer and the normal liver region (P0.05). All the parameters between the normal liver adjacent to cancer and normal liver region have no differences (P0.05). Conclusion Perfusion CT can provide quantitative information about arterial and portal blood flow of HCC.