Sequential Treatment for Helicobacter Pylori Eradication in Peptic Ulcer Patients

Objective To assessthe eradication andsafety of a10-day sequential regimencomparedwithconvention-al 7-day and 14-day triple therapies.Methods Overall,113 H.pylori-infected patients with peptic ulcer were enrolled.patients were randomized to receive 10-day sequential therapy〔pantoprazole(40 mg twice daily) plus amoxicillin(1 g twice daily) for the first 5 days followed by pantoprazole(20 mg),clarithromycin(500 mg) and tinidazole(500 mg) twice daily for the remaining 5 days〕or standard 7-day therapy(corrected) 〔pantoprazole(20 mg),clarithromycin(500 mg) andamoxicillin(1 g) twice daily〕,or standard 14-day therapy.Four weeks after therapy,H.pylori eradication was assessed by 14C-urea breath test.Adverse drug event were compared in three groups.Results H.pylori eradication was achieved in 36(92.3%) of 39 individuals in group A,34(97.1%) of 35 in group C and 27(73.0%) of 37 in group B.Sequential regimen and the 10-day showed a significant gain in the eradication rate as compared to the 7-day(P 0.05) while there was no significant difference between group A and group C(P 0.05).Adverse drug events were similar in these three regimens(P 0.05).Conclusion The sequential regimen and standard 14-day therapy achieved higher cure rate than standard 7-day therapy.The 10-day sequential regimen and 14-day triple therapies were more effective than 7-day triple therapies.