Expression of Estrogen-induced Protein PS2 in Infiltrating Ductal Breast Carcinoma and its Clinical Significance

To investigate the expression of estrogen-induced protein PS2 in infiltrating ductal breast carcinoma and the relationship with clinicopathological parameters. The expression of estrogen receptor (ER), progesterone receptor (PR) and PS2 in 155 cases with infiltrating ductal breast carcinoma were detected by the immunohistochemical technique(S-P). The positive expression of PS2 was found in 38.1% cases with infiltrating ductal breast carcinoma. The expression of PS2 was 48.6% in ER positive cases and 29.4% in ER negative cases(χ2=5.977, P0.05). The positive expression of PS2 was 50.8% in PR positive cases and 28.9% in PR negative cases(χ2=7.664, P0.01). The positive expression of PS2 was not correlated with patient's age, menopausal status, tumor size (P0.05), but its expression was realated to the status of axillary lymph node(P0.001) and clinical stage (P0.05). PS2 expression among different nationalities showed little difference, but no statistical significance. [Conclusion] The expression of PS2 in infiltrating ductal breast carcinoma is positively correlated with ER and PR, and its expression is also related to the status of axillary lymph node and clinical stage. PS2 may be used as an important marker for prognosis and endocrine treatment in breast cancer.