Relationship between oncogene C-erbB-2 expression and prognosis of infiltrating breast ductal cancer

Objective To explore the expression of oncogene C-erbB-2 in infiltrating breast ductal cancer tissues and the relationship with estrogen receptor(ER),progesterone receptor(PR),estrogen regulatory protein(PS-2),clinical stage,and axillary lymphnode involvement.Methods ER,PR,PS-2,and C-erbB-2 were stained by immunohistochemical technique.Pathological and clinical staging was carried out for every patient.The lymphnodes were examined pathohistologically.Results Tumors positive rate of ER-negative group was higher than that of ER-positive group(P 0.05).Tumors positive rate of PS-2 negative group was higher than that of PS-2 positive group(P 0.05).C-erbB-2 expression in infiltrating breast ductal cancer tissues was correlated positively with advanced clinical stages(P 0.05).C-erbB-2 expression in axillary lymphnode involvement-positive group was higher than lymphnode-negative group(P 0.05).Conclusion The values of ER,PR,PS-2,and C-erbB-2 in tumour tissue combining by each patient's clinical stage as well as pathological and immunohistochemical findings would be helpful to assessment and treatment of infiltrating breast ductal cancer.