Effects of Magnesium Isoglycyrrhizinate on hepatic reserve function in severe hepatitis patients

Objective To investigate the effects of Magnesium Isoglycyrrhizinate on hepatic reserve function in severe hepatitis patients.Methods 105 cases of severe hepatitis patients were divided into treatment group(n = 56) and control group(n = 49),both groups were received comprehensive medical treatment,and the treatment group were plus received injection of Magnesium Isoglycyrrhizinate of 200 mg per day for 4 weeks.The changes of liver function and hepatic reserve function were observed,and the fatality rate of the two groups was compared.Results The improvement of the liver function in the treatment group was better than the control group(P 0.05).Hepatic reserve function showed that the PTA level and the CHE level of the treatment group were significant improvement than those of the control group,but ALB level was not statistically changed between the two groups.The fatality rate was lower of the treatment group(51.8%) than the control group(75.5%,P 0.05).Conclusion The Magnesium Isoglycyrrhizinate can significantly improve liver function and the hepatic reserve function of the severe hepatitis patients,and reduce the fatality rate.