2009•Lishizhen Medicine and Materia Medica ResearchRequires access

Optimization of the Extraction Process of Oleanolic Acid from Fructus Forsythiae by Orthogonal Design

Xiong Shi-quan

Abstract

Objective To optimize the extraction condition of oleanolic acid from Fructus Forsythiae.Methods With oleanolic acid as index,extraction time、concentration of alcohol and amount of alcohol and were evaluated by L9(34)orthogonal design method.HPLC was used to analyze the content of oleanolic acid.Results The optimum extraction condition was described as follow:ultrasonic extraction 3 times(once 40 min),90% ethanol solution,and 12-fold solvent.Conclusion The optimized technology is quick and simple,and can be used for theoretical basic.

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Key concepts: Oleanolic acid, Chromatography, Extraction (chemistry), Alcohol, Solvent, Chemistry, Ethanol, High-performance liquid chromatography