Influence of Different Doses of Atorvastatin on the Prognosis of Unstable Angina

ObjectiveTo observe the influence of different doses of atorvastatin on the prognosis of unstable angina.Methods128 cases of patients treated with unstable angina from October 2005 to October 2008 were randomly divided into two groups of 64 cases of each group,the observation group with conventional therapy plus atorvastatin 40 mg/d,the control group with conventional treatment plus atorvastatin 20 mg/d.Both groups were measured before and after 90d treatment at the four lipids,C-reactive protein(CRP)and NO concentration,and were observed of Re-angina,myocardial infarction and cardiac death and other undesirable occurrence of cardiovascular events.ResultsThe lipid levels of two groups have varying degrees of reduction after treatment.Compared with the control group,the observation group is more obvious(P0.05).The two groups both reduce CRP and increase NO level after treatment.Compared with the control group,the effect of the observation group is more obvious(P0.05).With the occurrence of adverse events,the observation group decreased significantly compared with the control group(P0.05).ConclusionAtorvastatin therapy can improve prognosis of patients with unstable angina pectoris.40 mg dose every day is safe.Statin drug on prevention and control of coronary heart disease has important significance.