Clinical study of Dahuang Mugong decoction(大黄牡公汤) combined with sequential colon dialysis in treatment of chronic renal failure

Objective: To observe the clinical efficacy of combination of Dahuang Mugong decoction(DMD,大黄牡公汤) and sequential colon dialysis in treatment of chronic renal failure(CRF) and explore its potential mechanism.Methods: Nintyeight patients with CRF were treated with sequential colon dialysis and DMD.Besides the observation on the clinical symptoms and signs,the serum levels of blood urea nitrogen(BUN),serum creatinine(SCr),uric acid(UA),serum phosphorus((SP),inorganic),Ca~(2+) and(albumin)(Alb) were measured with autoanalysis machine and the optical density(A_(450) value) of medium molecule substance(MM) with(nephelometer) between pre treatment and posttreatment.Results: The(accumulated) score of the clinical symptoms and signs were decreased with the combination of DMD and(sequential) colon dialysis(P0.05 or P0.01).The serum(levels) of BUN,SCr,UA,SP and the A_(450) value of MM were(decreased) successfully(P0.01 or P0.05).The serum level of Ca~(2+),Alb and clearance of creatinine(CCr) were improved(P0.05 or P0.01).The serum levels of K~+,Na~+,Cl~-and body weight did not change significantly and there were no severe sideeffects in the course of treatment.In the therapy(36 cases) were remarkably improved,47 effective and 15 ineffective.The total effective rate was 84.69%.(Conclusion): DMD combined with sequential colon dialysis is an effective therapy for patients with CRF and the potential mechanism may be the action of colon dialysis and renal protection of rhubarb.