Determination of serum cTnI, CK-MB and hs-CRP and their implication in the clinical diagnosis of viral myocarditis

Objectives To evaluate the diagnostic value of co-detecting serum levels of cTnI,CK-MB and hs-CRP in viral myocarditis(VMC). Methods One hundred and fureteen children were divided into VMC group,suspected-VMC group and non-VMC group. Serum levels of cTnI,CK-MB and hs-CRP were detected in all the children. Results The serum levels of cTnI,CK-MB and hs-CRP in VMC group were much higher than those in non-VMC group(P 0.01=. There were no significant difference between serum levels of cTnI and CK-MB in VMC group and suspected-VMC group(P 0.05). The serum level of hs-CRP in VMC group was much higher than that in suspected-VMC group and non-VMC group(P 0.01=. The sensitivity rate was cTnI(81.4%) CK-MB(71.2%) hs-CRP(62.7%)and the specificity rate was hs-CRP(81.8%) cTnI(50.9%) CK-MB(43.6%). The specificity of co-detection of 3 indices(85.5%)was much higher than that of each single index. Conclusions Co-detection of serum levels of cTnI,CK-MB and hs-CRP is more specific than that of single index and it may enhance the accuracy of diagnosis for VMC.