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2009•Qilu Pharmaceutical AffairsRequires access

Determination of content and related substances of Lansuolazole Tablets by HPLC

Chang En-hui

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Abstract

OBJECTIVE To establish an HPLC method for the determination of the content and related substances of Lansuolazole Tablets.METHODS The HPLC system consisted of C18 column(4.6×250mm,5μm),water-acetonitrile-triethylamine(60∶40∶1),justed with phosphoric acid to a pH of 7.0 as mobile phase,the flow rate was 1.0mL·min-1.Detection wavelength was set at 285nm,the injection volume was 20μL and column temperature was 35℃.RESULTS The calibration curve was linear in the range of 19.76～177.84μg·mL-1(r=1);the average recoveries were 99.6% with corresponding RSD of 0.5%;the limit of detection was 0.02ng·mL-1.CONCLUSION The method was rapid,simple,accurate sensitive and suitable for the content and related substances determination of Lansuolazole Tablets.

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What this paper is about

OBJECTIVE To establish an HPLC method for the determination of the content and related substances of Lansuolazole Tablets.METHODS The HPLC system consisted of C18 column(4.6×250mm,5μm),water-acetonitrile-triethylamine(60∶40∶1),justed with phosphoric acid to a pH of 7.0 as mobile phase,the flow rate was 1.0mL·min-1.Detection wavelength was set at 285nm,the injection volume was 20μL and column temperature was 35℃.RESULTS The calibration curve was linear in the range of 19.76～177.84μg·mL-1(r=1);the average recoveries were 99.6% with corresponding RSD of 0.5%;the limit of detection was 0.02ng·mL-1.CONCLUSION The method was rapid,simple,accurate sensitive and suitable for the content and related substances determination of Lansuolazole Tablets.

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Available abstract

OBJECTIVE To establish an HPLC method for the determination of the content and related substances of Lansuolazole Tablets.METHODS The HPLC system consisted of C18 column(4.6×250mm,5μm),water-acetonitrile-triethylamine(60∶40∶1),justed with phosphoric acid to a pH of 7.0 as mobile phase,the flow rate was 1.0mL·min-1.Detection wavelength was set at 285nm,the injection volume was 20μL and column temperature was 35℃.RESULTS The calibration curve was linear in the range of 19.76～177.84μg·mL-1(r=1);the average recoveries were 99.6% with corresponding RSD of 0.5%;the limit of detection was 0.02ng·mL-1.CONCLUSION The method was rapid,simple,accurate sensitive and suitable for the content and related substances determination of Lansuolazole Tablets.

Key concepts: Chromatography, Calibration curve, Phosphoric acid, High-performance liquid chromatography, Triethylamine, Chemistry, Content determination, Detection limit

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