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2005•The Journal of Pharmaceutical PracticeRequires access

Determination of content in aripirazole tablets by HPLC

Cheng Yirig

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Abstract

Objective: To established a HPLC method for the determination of alipaizuo in its tablets. Method: Alipaizuo can be separated on column with a mixture of 0.02% phosphoric acid(pH =3.0, adjusted with triethylamine) and acetonitrile (46 : 54) as mobile phase and detected at 254 nm. Result:The linear range was from 2. 088μg/mL to 66. 816μg/mL (r =0. 999 99) for alipaizuo. The average recovery was 99. 39%. Conclusion: The method is simple, rapid, accurate and reliable.

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What this paper is about

Objective: To established a HPLC method for the determination of alipaizuo in its tablets. Method: Alipaizuo can be separated on column with a mixture of 0.02% phosphoric acid(pH =3.0, adjusted with triethylamine) and acetonitrile (46 : 54) as mobile phase and detected at 254 nm. Result:The linear range was from 2. 088μg/mL to 66. 816μg/mL (r =0. 999 99) for alipaizuo. The average recovery was 99. 39%. Conclusion: The method is simple, rapid, accurate and reliable.

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Available abstract

Objective: To established a HPLC method for the determination of alipaizuo in its tablets. Method: Alipaizuo can be separated on column with a mixture of 0.02% phosphoric acid(pH =3.0, adjusted with triethylamine) and acetonitrile (46 : 54) as mobile phase and detected at 254 nm. Result:The linear range was from 2. 088μg/mL to 66. 816μg/mL (r =0. 999 99) for alipaizuo. The average recovery was 99. 39%. Conclusion: The method is simple, rapid, accurate and reliable.

Key concepts: Triethylamine, Phosphoric acid, Chromatography, High-performance liquid chromatography, Acetonitrile, Chemistry, Content determination, Linear range

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