Diagnosis and blood therapy of Rh(D/E)hemolytic diseases caused by maternal-fetal blood group incompatibility

Objective:To investigate the therapy of Rh(D/E)hemolytic diseases caused by maternal-fetal blood group incompatibility,prevent the spontaneous abortion and fatal death.Methods:A substitution transfusion special by multiplicity removal and manipulus replenishment was used for the therapy of Rh(D/E)hemolytic diseases caused by maternal-fetal blood group incompatibility,it could cut down the quantity of special anti-D/E IgG,improve the survival rate of fetus and newborns.Results:Two mothers with Rh(D)hemolytic diseases had high titer anti-D IgG(1∶512 and 1∶1 024)before substitution transfusion,but it decreased to(1∶16 and 1∶32)3 weeks after substitution transfusion,and their low anti-D IgG(≤64)were maintained after treated with interval substitution transfusion,by the end they give birth to a male and a female baby with uterine-incision delivery.A Rh(E)hemolytic diseases mother who did treated with substitution transfusion ended her pregnancy by dead fetus in uterus,another Rh(D)hemolytic diseases mother without substitution transfusion deliver a baby with Rh(D)hemolytic diseases,who was survived after substitution transfusion.Three children were health after 1 year's follow-up visiting.Conclusion:Substitution transfusion with multiplicity removal and manipulus replenishment,company with high protein food is a efficient therapy for Rh(D/E)hemolytic diseases mother,and it is a best choice for newborns with Rh(D/E)hemolytic diseases.