Exchange transfusion with Rh positive blood for neonatal Rh hemolytic disease

Objective To confirm whether exchange transfusion(ET) with Rh positive blood is better than the traditional therapy for neonatal Rh hemolytic disease.Methods All cases of Rh hemolytic disease registered in our ward during 1987～2001?some got ET with Rh negative blood other got ET with Rh positive blood.The way of exchange transfusion,blood type,effect and prognosis were compared respectively.Results During 1987～1999,eleven neonates underwent ET of Rh negative through cord vessels(NB group);nine neonates taken ET of Rh positive through peripheral vessels(PB group).In both groups, serum bilirubin(TB) declined significantly after ET( P 0 001).The decreasing rate of TB in PB group was 0.53±0 08,which was greater than that of NB group(0.28±0 29);hospitalization time of PB group were ( 10.56 ±1.42)days, shorter than NB group′s (17.18±7.16)days;blood quantity of PB group was (488.89±124.44)ml,higher than NB group′s (354.45±129.06)ml.All the differences were significant( P 0.05).Conclusion ET with Rh positive through peripheral vessels was more timing and effective for treatment of neonatal Rh hemolytic disease.