Clinical efficacy of high-dose omeprazole for 78 senile cases of gastric ulcer with hemorrhage

Objective To analyze the clinical efficacy of high-dose omeprazole in treating 78 senile cases of gastric ulcer with hemorrhage.Methods From Jun.2009 to Jun.2012,78 elderly cases of ulcer with hemorrhage treated in our hospital were selected and randomly divided into observation group and control group,39 cases for each group.Both group received conventional therapy.Control group received omeprazole,40 mg for intravenous administration,12 hourly.Observation group received high-dose omeprazol,80 mg for initial intravenous injection,then for intravenous administration at the speed of 8 mg / h.Both groups were treated for 3days and received oral omeprazole,20 mg,once daily.The treatment course lasted 1month.Measurement data were processed by t-test,count data by χ2test,the result of P 0.05 was considered statistically significant.Results After treatment,the rate or re-bleeding was 7.69%,0 and 0 respectively within3 days,during 4 ~ 30 d and during 31 d ~ 3m in observation group,which was significantly lower than that in control group(20.51%,5.13%,2.56%)(P 0.05).The total effective rate was 94.87% in observation group and 6.92% in the controls,the difference was statistically significant(P 0.05).Conclusions High-dose omeprazole for gastric ulcer with bleeding in the elderly can effectively improve the clinical efficacy,and reduce the risk of re-bleeding,which is suitable for clinical application.