Effect observation of Valsartan and Vitamin E in treatment of Diabetic nephropathy

Objective: To observe the clinical efficacy of combination of Valsartan and Vitamin E on treating diabetic nephropathy. Methods: 80 patients with diabetic nephropathy were randomly divided into two groups, treatment group (n= 41) and control group (n=39), they were routinely treated with general treatment for diabetic. The treatment group was given 80 mg Valsartan daily, plus 0.1 g Vitamin E daily; the control group was given 80 mg Valsartan daily alone. 3 months courses of treatment, the observed indicators were 24 h urinary albumin eliminate rate, blood urea nitrogen, serum creatine and so on the indicators change were compared in two groups. Results: There was a decrease of 24 h UAER after 3 months of treatment in two groups (P0.05, P0.01), more significant in treatment group compared to that of control groups (P0.05), blood urea nitrogen and serum creatine didn′t show statistical difference between two groups (P0.05). Conclusion: The combination of Valsartan and Vitamin E is effective in the therapy of diabetic nephropathy, which can decrease urinary albumin, it is superior to Valsatan alone.