2013•Journal of clinical and experimental medicineRequires access
Clinical observation on the efficacy of alprostadil combined with valsartan in treatment of diabetic nephropathy
LU Ron
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Abstract
Objective To observe the clinical efficacy of alprostadil combined with valsartan in treatment of patients with diabetic nephropathy.Methods A total of 74 patients with diabetic nephropathy were randomly divided into two groups.Patients in control group were treated with valsartan on the basis of basic treatment,and patients in observation group were treated with alprostadil and valsartan on the basis of basic treatment.The course of treatment in two groups was 3 months.The changes in 24 h urinary protein excretion(24 h Upr),blood levels of urea nitrogen(BUN) and creatinine(Cr) in two groups were observed before and after treatment.Results The total rate of efficacy in patients of observation group(81.1%) was significantly higher than that of patients in control group(64.9%)(P 0.05).The indicators of 24 h Upr,Scr and BUN in patients of two groups were all decreased,but the indicator of 24 h Upr in patients of observation group declined more significantly than that of control group(P 0.05).Conclusion The treatment of alprostadil combined with valsartan for diabetic nephropathy has good efficacy.It is worthy to be recommended for clinical application.