Relationship between oncogene Stat3 and invasion and metastasis of non-small cell lung cancer

Objective To investigate the expressions of Stat3, CyclinD1 and proliferating cell nuclear antigen (PCNA) in non-small cell lung cancer (NSCLC), and analyze their relationships with carcinogenesis and progression of NSCLC. Methods SP immunohistochemistry was used to detect the expressions of Stat3, CyclinD1 and PCNA in 45 cases of NSCLC. Results The positive rate of Stat3 was 71. 1 % in NSCLC. The expression intensities of Stat3 was not associated with different tumor sizes and histological type, but it was associated with the expression intensities of CyclinDi and PCNA (r= 0.531, P0. 01; r= 0.618, P0. 01) and it was related to histological grade and lymph node metastasis (P0. 05). Conclusion The expression of Stat3 is abnormal in NSCLC. Stat3 may involve in regulation of CyclinDi in NSCLC and accelerate proliferation of NSCLC, it may play an important role in generation of NSCLC.