The expression of VEGF,bFGF and MVD in human malignant melanoma and their clinicopathological significance

Objective:To investigate the relationship between the expression of vascular endothelial growth factor(VEGF),basic fibroblast growth factor(bFGF)and microvessel density(MVD)in human malignant melanoma(MM).Methods:Tissue sections from 42 MM patients were examined.The expression of VEGF,bFGF was detected using immunohistochemistry technique and morphological quantitative analysis of MVD was also counted by vascular endothelial cell immunostaining with anti-FⅧ-RAg antibody.Results:In 42 specimens of MM tissue,VEGF was expressed in 32 specimens,bFGF was expressed in 29 specimens and 25 specimens expressed the both.There was no expression of VEGF、bFGF in nevus pigmentosus.The MVD of MM was significantly higher than that of pigmented mole.Conclusion:The number of the MVD increases along with the high expression of VEGF and bFGF in MM.There is positive correlation between VEGF and bFGF.There is a relationship between the expression of VEGF,bFGF and the metastasis of lymph node.