Effects of Perilla Seed Extracts on the Blood Fat and Lipid Peroxidation of Rabbit with Hyperlipidemia

[Objective] The aim was to observe the control effect of perilla seed extracts(EPS) on the hyperlipidemia of rabbits.[Method] The high fat and cholesterol diet were adopted to build the hyperlipidemia model of rabbit.The rabbits were randomly and equally divided into 5 groups which were NC(normal control) group,HLM(high lipid model) group,EPSⅠ,EPSⅡ and EPS Ⅲ group(low,middle,high dose of 0.1 g/ml,0.5 g/ml and 1.0 g/ml EPS respectively).The contents of TC,TG,LDL-C and HDL-C in serum and the contents of MDA,the activity of SOD in liver homogenate were detected respectively.[Result]The EPS groups could significantly decrease the contents of TC,TG and LDL-C and improve the contents of HDL-C;reduce the contents of MDA and improve the activity of SOD.[Conclusion] EPS could regulate blood fat and control act lipid peroxidation.