The Effect of the Extractions of Perilla Seed on Rabbit Nonalcoholic Fatty Liver Disease

The experiment was aimed at reseach the treatment effects of the extractions of Perilla Seed(EPS) on the rabbits with nonalcoholic fatty liver disease(NAFLD)which induced by high lipid diet.The rabbits were randomly and equally divided into 3 groups which were normal control(NC) group,high lipid model(HLM) group,EPS group(EPS 0.1 g/mL).The contents of TC,TG,LDL-C,HDL-C,ALT,AST in the serum of three groups were detected and compared.The hepatic tissue was fixed by formalin,embedded with paraffin,sectioned,stained with H.E.,and observed under optical microscope to evaluate the degree of hepatic steatosis.The results showed that EPS could significantly decrease the contents of TC,TG,LDL-C,ALT,SAT,increase the contents of HDL-C in serum(P0.01,or P0.05),and alleviate the degree of hepatic steatosis(P0.01).It indicted that EPS could resist the NAFLD caused by experimental hyperlipidemia in rabbits.The mechanisms might be related with its regulating effect for dyslipidemia and inhibition effect for fat accumulation in liver.